Parasitic Diseases List

PROTECT YOUR PETS: Heartworm is on the rise as spring weather creeps in KSNT News With the warmer temperatures, come more of those pesky mosquitos. However, we're not the only ones who feel their effects. A local veterinarian is reminding ...

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The NMDA receptor regulates integrin activation, ATP release and arterial thrombosis through store-operated Ca2+ ... - Frontiers

July 04, 2024

1. Introduction Platelets are anuclear cells with a crucial role in hemostasis and thrombosis. Platelet activation and aggregation is important to stop bleeding following vessel injury, but can also trigger pathological thrombus formation to provoke thrombosis. Consequently, platelets play a dominant role in cardiovascular diseases including myocardial infarction, stroke or abdominal aortic aneurysm (1–6). Cytosolic calcium is a second messenger important for many (patho-) physiological processes in platelets (7), including integrin activation, cytoskeletal reorganization, degranulation, pro-coagulant activity and thrombus formation (8–11). Ca 2+ signaling is activated through activation of GPVI, thrombin receptors and purinergic receptors including P2Y1, P2Y12 and P2X1 at the platelet membrane leading to intracellular signaling cascades including the phosphorylation of PLC (8, 12). A variety of hormones and growth factors stimulate the hydrolysis of phosphatidylinositol 4, 5-bispho...

Ancient Malaria Genome from Roman Skeleton Hints at Disease's History - Scientific American

March 16, 2024

March 15, 2024 3 min read Genetic information from ancient Roman remains is helping to reveal how malaria has moved and evolved alongside people By Tosin Thompson & Nature magazine Malaria, an endemic disease caused by hematozoic parasites (Plasmodium falciparum) transmitted by the blood to humans through the bite of the female anophele mosquito. Credit: BSIP SA/Alamy Stock Photo Researchers have sequenced the mitochondrial genome of the deadliest form of malaria from an ancient Roman skeleton. They say the results could help to untangle the history of the disease in Europe. It's difficult to find signs of malaria in ancient human remains, and DNA from the malaria-causing parasite Plasmodium rarely shows up in them. As a result, there had never been a complete genomic sequence of the deadliest species, Plasmodium falciparum , from before the twentieth century — until now. " P. falciparum was eliminated in Europe a half century ago, and genetic data from European pa...