Misdiagnosis of von Willebrand disease | JBM - Dove Medical Press
Introduction von Willebrand disease (VWD) is the most common inherited bleeding disorder. 1,2 Despite this, VWD is one of the most commonly misdiagnosed or overlooked entities in everyday clinical practice. Of interest, VWD may be both over- and under-diagnosed, as well as misdiagnosed, either as another entity or as a different subtype of the disorder. This review will detail the causes underlying the diagnostic uncertainties overshadowing VWD and provide solutions on how to overcome these. von Willebrand Disease VWD was first described by Finnish physician Erik Adolf von Willebrand in 1926, following the presentation of a young girl with recurrent episodes of bleeding, which were clinically distinct from haemophilia. 3 VWD is caused by quantitative or qualitative deficiencies in a plasma protein now called von Willebrand factor (VWF). VWF is a large, complex protein that has essential roles in primary and secondary hemostasis. 4 High-molecular-weight VWF multimers mediate ...