Updated C. Difficile Infection Guidelines Incorporate New Trials - Pharmacy Times
Clostridioides difficile is a gram-positive, spore-forming, toxin-producing anaerobic bacterium that causes antibiotic-associated diarrhea. 1,2 C.difficile infection (CDI) may occur when the human intestinal tract is disrupted by broad-spectrum antibiotics.1,2 Certain antibiotic agents, such as clindamycin, fluoroquinolones, and some cephalosporins, are known to have the highest risk of causing antibiotic-associated diarrhea. 3 Depending on the host, the infection can range from being asymptomatic to life-threatening C. difficile colitis.1,2 Untreated CDI can lead to serious complications, including death, perforations of the colon, pseudomembranous colitis, sepsis, and toxic megacolon. 4 The Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America began updating the clinical practice guidelines for the management of C. difficile in early 2019 to incorporate new randomized control trials that compared C. difficile agents. This update contains...